NK 2019 Programme

Dowload the programme in pdf

Monday 30.09.2019

14:00 - 19:00    Registration open 
17:00 - 17:30    Welcome
17:30 - 18:30    Keynote Lecture
                           Chairperson: Markus Ollert
                           Speaker: Jean-Laurent Casanova: "Toward a genetic theory of childhood infectious diseases”
19:00                 Welcome Cocktail

Tuesday 01.10.2019

08:30 - 10:00       SESSION 1 - NK Cell Receptors and Education

Chairpersons: Thierry Walzer, Domenico Mavilio

- 08:30 - 08:50    Katharine Hsu: "New insights to old ideas in NK education"
- 08:50 - 09:10   Jacques Zimmer: "Imprint of education on activated natural killer cells"
- 09:10 - 09:20   Selected short talk 1 - Sytse Piersma:  “Activation Receptor-dependent IFNγ Production by NK Cells is Controlled by Transcription, Translation and the Proteasome”
- 09:20 - 09:40   Peter Parham: “Interactions of KIR, HLA class I and Disease”
- 09:40 - 10:00   Karl-Johan Malmberg: "Functional diversification of human NK cells through lysosomal maturation and remodeling"

10.00 - 10.30       COFFEE BREAK
 
10:30 - 12:00       SESSION 2 - NK Cell Development and Differentiation

Chairpersons: Aharon Freud, Cynthia Dunbar

-10:30 - 10:50    Catherine Blish: “Tuning the human natural killer response to viral infection”
-10:50 - 11:00    Selected short talk 2 - Bethany Mundy-Bosse : “Epigenetic Dysregulation of EBV(+) Extranodal NK/T cell Lymphoma Defines Distinct Subsets of Disease”
-11:00 - 11:20    Emily Mace: “New insights into requirements for adhesion and migration in human NK cell development”
-11:20 - 11:30    Selected short talk 3 - Geoffrey Guittard: ”Targeting CIS in NK cells improves their anti-tumor functions without impairing homeostasis”
-11:30 - 11:50    Michael A. Caligiuri: "A missing link: Why PD-L1 negative tumors respond to anti-PD-L1"
-11:50 - 12:00    Selected short talk 4 - Philippa Kennedy: ”A tri-specific killer engager (TriKE) against mesothelin targets NK cells towards lung cancer”

12:00 - 13:30       LUNCH
 
13:30 - 15:00       SESSION 3 - Innate Lymphoid Cells

Chairpersons: Nathalie Jacobs, Evelyn Ullrich

-13:30 - 13:50    Mariapia Degli-Esposti: “NK cell regulation of inflammatory responses”
-13:50 - 14:10    Christian Vosshenrich: “ILC development – from a T cell perspective”
-14:10 - 14:20    Selected short talk 5 - Selma Boulenouar: “High-fat diet causes rapid microbiota-dependent intestinal ILC3 loss and impairs tolerance and immunity”
-14:20 - 14:40    Marco Colonna: "NCRs Ligands"
-14:40 - 15:00    Andreas Diefenbach: “Control of tissue homeostasis and growth by innate lymphoid cells”

15:00 - 15:30       COFFEE BREAK
 
15:30 - 17:00       SESSION 4 - NK cells and Metabolism

Chairpersons: Sophie Ugolini, Dirk Brenner

-15:30 - 15:50    Greta Guarda: “Novel mechanisms regulating NK cell immunity”
-15:50 - 16:00    Selected short talk 6 - Luana Guerra: “Glutathione modulates Natural Killer cell function”
-16:00 - 16:20    Clair M. Gardiner: “How cancer impacts on NK cell metabolism”
-16:20 - 16:30    Selected short talk 7 - Andrew Highton: ”Distinct Metabolic Profiles in Differentially Educated NK Cell Populations”
-16:30 - 16:50    Megan A. Cooper: “Metabolic regulation of NK cell anti-viral functions”
-16:50 - 17:00    Selected short talk 8 - Laurent Brossay: “KLRG1 as a novel checkpoint inhibitor target“

17:00 - 19:00       FREE TIME
19:00                   POSTER SESSION 1

Wednesday 02.10.2019

08:30 - 10:00       SESSION 5 - NK Cells and Anti-Tumour Immunity

Chairpersons: Massimo Vitale, Christian Vosshenrich

-08:30 - 08:50    Adelheid Cerwenka: “Exploiting Natural Killer cell functional heterogeneity in cancer“
-08:50 - 09:10    David H. Raulet: "NK cell activation and inactivation in the tumor microenvironment: Potential for mobilizing NK cells for cancer therapy”
-09:10 - 09:20    Selected short talk 9 - Karoliina Tuomela: ”Radiotherapy induces resistance to NK cell cytotoxicity”
-09:20 - 09:40    Jordan S. Orange: “Advances in the mechanics of NK cell cytotoxicity”
-09:40 - 10:00    Carsten Watzl: “Insights into the cytotoxic mechanisms of NK cells“

 

10.00 - 10.30       COFFEE BREAK

 

10:30 - 12:00      SESSION 6 - NK cell Memory

Chairpersons: Frank Cichocki, Yenan Bryceson

-10:30 - 10:50    Joseph C. Sun: "Molecular mechanisms controlling adaptive NK cell responses"
-10:50 - 11:00    Selected short talk 10 - Endi Santosa:” Themis2 regulates innate and adaptive lymphocyte responses during viral infection”
-11:00 - 11:20    Silke Paust: "NK memory to HIV"
-11:20 - 11:30    Selected short talk 11 -Vanda Juranic Lisnic: “Altered-self MHC I molecules in MCMV evasion of NK cells and evolution of virus-specific Ly49 receptors”
-11:30 - 11:50    Todd A. Fehniger: "Cytokine-Induced Memory-Like NK cells"
-11:50 - 12:00    Selected short talk 12 - Alvaro Haroun-Izquierdo: “Efficient Scale-up and Pre-clinical Evaluation of NKG2C+ Adaptive NK Cell Expansion for Therapy Against High-risk AML/MDS”

 

12:00 - 13:30       LUNCH

 

13:30 - 15:00       SESSION 7 - NK Cell Immunotherapy and Immunomodulation

Chairpersons: Angela Santoni, Bassam Janji


-13:30 - 13.50    Eric Vivier: “Manipulation of Natural Killer cells in Cancer”
-13:50 - 14:10    Kathy Rezvani: “Next generation engineered NK cell therapies for the treatment of cancer”
-14:10 - 14:20    Selected short talk 13 - Pauline Rettman :” A DNA vaccine targeting KIR2DS2 activates NK cells and inhibits tumour growth”
-14:20 - 14:40    Winfried Wels: ”CAR-engineered NK cells: Off-the-shelf therapeutics bridging innate and adaptive immunity”
-14:40 - 15:00    Zhigang Tian: “NK Cell Exhaustion and Reversal in Tumor Immunotherapy”

 

15:00 - 17:00       POSTER SESSION 2 
17:00 - 19:30       SOCIAL EVENT
19:30                   GALA DINNER

Thursday 03.10.2019

08:30 - 10:00       SESSION 8 - Tissue-associated NK Cell Subsets

Chairpersons: Ana Stojanovic, Niklas Björkström


-08:30 - 08:50    Wayne Yokoyama: “Tissue-resident NK cells in the pregnant uterus.”
-08:50 - 09:00    Selected short talk 14 - Anaïs Eberhardt: “Interleukin-33 is a novel activator of a subset of polyfunctional NK cells with anti-tumor activity”
-09:00 - 09:10    Selected short talk 15 - Ayad Ali: ”A LAGging sensation prevents overexuberant immune regulation by splenic NK cells
-09:10 - 09:20    Selected short talk 16 - John Sunwoo: ”Heterogeneity of NK Cells and Innate Lymphoid Cells in the Tissue Microenvironment of Human Tumors”
-09:20 - 09:40    Ashley Moffett. “On the Frontier: No Hard Border between the Mother and her Fetus”
-09:40 - 09:50    Selected short talk 17 - Ana Espino: ”Interplay between Zika Virus and Decidual Natural Killer cells at the human maternal-fetal interface”
-09:50 - 10:00    Selected short talk 18 - Silvia Pesce: “Relevant role for PD-1 immune checkpoint expressed on NK cells derived from ovarian cancer patients”

 

10.00 - 10.30       COFFEE BREAK

 

10:30 - 12:00       SESSION 9 - NK Cells and Infection

Chairpersons: Eleanor Riley, Stipan Jonjic

-10:30 - 10:50    Chiara Romagnani: “CMV imprinting of NK cells signatures”
-10:50 - 11:10    Lewis L. Lanier: “NK cell interaction with MHC class I-negative cells”
-11:10 - 11:20    Selected short talk 19 - Helen Wagstaffe: ” Ebola Virus Glycoprotein Stimulates IL-18 Dependent Natural Killer Cell Responses”
-11:20 - 11:40    Marcus Altfeld: “Regulation of NK cell activation by HLA class II and non-classical HLA class I”
-11:40 - 12:00    Christopher H. Mody: "Direct fungal killing by human NK cells"

 

12:00 - 13:30       LUNCH

 

13:30 - 15:00       SESSION 10 - NK cells in clinics

Chairpersons: Nick Huntington, Salim Khakoo

-13:30 - 13:50    Ulrike Köhl: “CAR expressing NK cells for cancer retargeting”
-13:50 - 14:10    Jeffrey Miller: "Enhancing NK Cell Specificity With Off-the-Shelf engagers (TrIKEs) and iPS derived NK"
-14:10 - 14:20    Selected short talk 20 - Aura Muntasell : ”Predictive value of tumor-associated and circulating NK cells for neoadjuvant therapy response in primary HER2-positive breast cancer patients”
-14:20 - 14:40    Dean Lee: “Genetic, epigenetic, and non-genetic reprogramming of NK cells for therapeutic application”
-14:40 - 15:00    Hans Gustaf Ljunggren: ”Autologous NK cell-based adoptive immunotherapies in human lymphoid malignancies”

 

15:00 - 15:30       Concluding remarks and invitation to the next NK meeting